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Why Some Cancers May Respond Poorly to Key Drugs Discovered

Why Some Cancers May Respond Poorly to Key Drugs Discovered

Patients with BRCA1/2 mutations are at higher risk for breast, ovarian and prostate cancers that can be aggressive when they develop – and, in many cases, resistant to lifesaving drugs. Now scientists at The University of Texas at Austin and Ajou University in South Korea have identified a driver of the drug resistance that can make a life or death difference for patients with these cancers.

Antibody Test Developed for COVID-19 That is Sensitive, Specific and Scalable

Antibody Test Developed for COVID-19 That is Sensitive, Specific and Scalable

An antibody test for the virus that causes COVID-19, developed by researchers at The University of Texas at Austin in collaboration with Houston Methodist and other institutions, is more accurate and can handle a much larger number of donor samples at lower overall cost than standard antibody tests currently in use. In the near term, the test can be used to accurately identify the best donors for convalescent plasma therapy and measure how well candidate vaccines and other therapies elicit an immune response.

Researchers Discover Key Mechanism Cells Use to Harness Energy

Researchers Discover Key Mechanism Cells Use to Harness Energy

Scientists have known for some time that NAD+ (oxidized nicotinamide adenine dinucleotide), a key molecule involved in the function of all cellular life, is needed to help cells harness energy. What scientists didn't fully understand until now is how human cells compartmentalized intracellular NAD+ or that – as a new paper out today in the journal Nature suggests – the process may be able to be controlled to help address aging and diseases, from neurodegeneration to cancer.

Matching CRISPR to the Job Improves the Safety, Efficiency of the Gene-Editing Tool

Matching CRISPR to the Job Improves the Safety, Efficiency of the Gene-Editing Tool

One of the biggest scientific advances of the last decade is getting better thanks to researchers at The University of Texas at Austin; the University of California, Berkeley; and Korea University. The team has developed a new tool to help scientists choose the best available gene-editing option for a given job, making the technology called CRISPR safer, cheaper and more efficient. The tool is outlined in a paper out today in Nature Biotechnology.

UT Austin Will Test More Than 5,000 a Week for COVID-19

UT Austin Will Test More Than 5,000 a Week for COVID-19

Samples are loaded into a liquid handling robot at the High Throughput Testing Core (HTTC) on campus. Photo by Vivian Abagiu.

When the novel coronavirus began spreading across the United States this spring, The University of Texas at Austin quickly purchased three state-of-the-art robots and assembled additional equipment capable of processing hundreds of COVID-19 test samples every day.

State Cancer Research Grant Awarded to Molecular Bioscientist

State Cancer Research Grant Awarded to Molecular Bioscientist

Cancer research is getting a boost at The University of Texas at Austin as researchers in the College of Natural Sciences and Dell Medical School received grants from the Cancer Prevention and Research Institute of Texas (CPRIT).

Ask the COVID-19 Experts (Audio)

Ask the COVID-19 Experts (Audio)

We asked you, dear listeners, to send us your most burning questions about COVID-19. And you didn't disappoint. You asked: When will it be safe for my 12-week-old baby to meet her grandparents? Can you catch it twice? Is the virus mutating and will that make it harder to develop vaccines? In today's episode, our three experts get to the bottom of these questions, and more.

Some Bacteria Sacrifice Themselves to Protect their Brethren from Antibiotics

Some Bacteria Sacrifice Themselves to Protect their Brethren from Antibiotics

Scientists at The University of Texas at Austin have discovered how some cells within a bacterial swarm will sacrifice themselves so that other cells in the swarm have a better chance of surviving onslaught by antibiotics, in a discovery important for efforts to address antibiotic resistance.

Tiny Insects Provide Inspiration for New Biomaterials

Tiny Insects Provide Inspiration for New Biomaterials

Oncometopia hamiltoni leafhopper insect. Photo by Alex Wild, used with permission.

They may be tiny, but leafhoppers have a super power: they secrete a substance that makes their bodies water-repellant and anti-reflective, which may help them blend in with their surroundings and escape surface tension. Symbiotic bacteria living in the leafhoppers appear to assist in producing the substance and its soccer-ball-shaped nanostructures called brochosomes, but the process is something of a mystery.

Locking Down Shape-Shifting Spike Protein Aids Development of COVID-19 Vaccine

Locking Down Shape-Shifting Spike Protein Aids Development of COVID-19 Vaccine

An engineered protein developed by UT Austin researchers and their colleagues is a key element of COVID-19 vaccines currently in human trials by Moderna, Novavax, Pfizer-BioNTech and Johnson & Johnson.

The experimental vaccine against SARS-CoV-2 that was the first to enter human trials in the United States has been shown to elicit neutralizing antibodies and a helpful T-cell response with the aid of a carefully engineered spike protein that mimics the infection-spreading part of the virus.