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Potential New Gene Editing Tools Uncovered

Potential New Gene Editing Tools Uncovered

Scientists have found over a thousand versions of a natural gene editor in bacteria, which could lead to better gene editing tools to treat diseases. Image courtesy: National Human Genome Research Institute.

Few developments have rocked the biotechnology world or generated as much buzz as the discovery of CRISPR-Cas systems, a breakthrough in gene editing recognized in 2020 with a Nobel Prize. But these systems that naturally occur in bacteria are limited because they can make only small tweaks to genes. In recent years, scientists discovered a different system in bacteria that might lead to even more powerful methods for gene editing, given its unique ability to insert genes or whole sections of DNA in a genome.

UT Austin Harnesses Power of Biology in Partnership with Army Research Laboratory

UT Austin Harnesses Power of Biology in Partnership with Army Research Laboratory

Jimmy Gollihar at work in the "biological foundry." Photo credit: Callie Richmond.

Early last year, Jimmy Gollihar was deep into building a unique facility on the Forty Acres, what he calls "the biological foundry" – a turbo-charged, biotech playground with a focus on rapid scientific discovery. The foundry was to be a key element of a partnership in synthetic biology research between The University of Texas at Austin and the U.S. military. Then, as fate would have it, COVID-19 would change everything.

Breakthrough in Fight on Tick-Borne CCHF Virus is Latest Use of New Strategy Against Diseases

Breakthrough in Fight on Tick-Borne CCHF Virus is Latest Use of New Strategy Against Diseases

A 3D atomic map, or structure, of the Gc protein (red and yellow) bound to two antibodies (green, blue and white) produced by a recovered patient. The Gc protein is a key molecule on the surface of the CCHF virus enabling it to infect cells. Credit: Akaash Mishra/University of Texas at Austin

Using the same approach they recently used to create effective vaccine candidates against COVID-19 and respiratory syncytial virus (RSV), scientists are tackling another virus: the tick-borne Crimean-Congo hemorrhagic fever (CCHF). It causes death in up to 40% of cases, and the World Health Organization identified the disease as one of its top priorities for research and development. The results appear today in the journal Science.

A Celebration of Science and Health Heroes

A Celebration of Science and Health Heroes

The UT Tower shined bright with burnt orange lights in October to honor the researchers who helped create the COVID-19 vaccines.

Austin Mayor Steve Adler, Medical Director Desmar Walkes, world-changing scientists and members of the UT Austin Community are gathering to celebrate the hard-working people on campus and beyond who have contributed to COVID-19 vaccines and vaccinations. The College of Natural Sciences' Vaccination Celebration recognizes the UT Austin connection to vaccine development and the progress that has been made in getting people vaccinated almost one year since the global vaccine rollout began. The event also features a vaccine pop-up, as well as a free concert by Austin-based band Nané.

Molecular Biosciences Professor Honored for Outstanding Teaching

Molecular Biosciences Professor Honored for Outstanding Teaching

Janice Fischer, professor of molecular biosciences and director of the Biology Instructional Office at The University of Texas at Austin, has won a UT System Regents' Outstanding Teaching Award.

McLellan Honored for Contributions to COVID-19 Vaccines

McLellan Honored for Contributions to COVID-19 Vaccines

Photo by Vivian Abagiu

Jason McLellan, UT Austin molecular biosciences professor, has received the 2021 Shirley Bird Perry Longhorn Citizenship Award, recognizing the wide-reaching impact of his work with viral proteins, especially his contributions to COVID-19 vaccines. The award is given annually by UT Austin's Annette Strauss Institute for Civic Life.

Announcing the 2021 Stengl-Wyer Scholars, Fellows and Grant Awardees

Announcing the 2021 Stengl-Wyer Scholars, Fellows and Grant Awardees

Funded by the Stengl-Wyer Endowment, the Stengl Wyer Postdoctoral Scholars Program provides up to three years of independent support for talented postdoctoral researchers in the broad area of the diversity of life and/or organisms in their natural environments. The endowment also supports year-long fellowships for doctoral candidates pursuing dissertation research in the same area.

Innovative Cancer Research Bolstered by Grants from CPRIT

Innovative Cancer Research Bolstered by Grants from CPRIT

A slice through a cluster of about 20 human cells with mitochondria highlighted as green and red dots. Image courtesy of Lulu Cambronne/University of Texas at Austin.

The Cancer Prevention and Research Institute of Texas (CPRIT) recently awarded grants to six faculty members at The University of Texas at Austin, including Xioalu "Lulu" Cambronne in the Department of Molecular Biosciences. The funding will support ongoing, innovative cancer research at UT Austin and enable advances in immunotherapy, drug development and cancer prevention efforts.

As Cryo-EM Capabilities Expand, Cool Science at UT Gets a Boost

As Cryo-EM Capabilities Expand, Cool Science at UT Gets a Boost

David Taylor with the Glacios cryo-EM. Photo credit: Vivian Abagiu.

Imagine biological and chemical imaging tools so advanced that they are able to show the molecular details of a virus as it attaches to and enters cells, or the alignment of vanishingly tiny crystals at an atomic level so as to lend insights for new solar energy technology.

Bacterial Warfare Provides New Antibiotic Target

Bacterial Warfare Provides New Antibiotic Target

Pseudomonas bacteria use a kind of harpoon to attack nearby bacteria, injecting them with a toxin that targets a critical molecular machine called the transamidosome complex. Credit: Despoina Mavridou/University of Texas at Austin.

Antibiotic resistance, where disease-causing bacteria evolve resistance to drugs that usually kill them, is a rising problem globally, meaning new antibiotics need to be found. However, it is difficult for researchers to know which parts of bacterial cells to target with new drugs.