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From the College of Natural Sciences
Bringing Developmental Biology to South Texas

Bringing Developmental Biology to South Texas

Over the last two decades, John Wallingford has taught developmental biology short courses to students at two of the country's most highly prestigious and competitive biological research institutions: the Marine Biological Laboratory in Woods Hole, Massachusetts, and the Cold Spring Harbor Laboratory in New York. But not all biology students have access to these transformative experiences.

Students in the Baffin Bay Developmental Biology short course in Kingsville, TX in August 2022. Photo credit: Miranda Smith.
DNA Barcodes That Reliably Work: A Game-Changer for Biomedical Research

DNA Barcodes That Reliably Work: A Game-Changer for Biomedical Research

This illustration shows the most common structure of DNA found in a cell, called B-DNA. Credit: Richard Wheeler (Zephyris). Used under the Creative Commons Attribution-ShareAlike 3.0 license.

In the same way that barcodes on your groceries help stores know what's in your cart, DNA barcodes help biologists attach genetic labels to biological molecules to do their own tracking during research, including of how a cancerous tumor evolves, how organs develop or which drug candidates actually work. Unfortunately with current methods, many DNA barcodes have a reliability problem much worse than your corner grocer's. They contain errors about 10 percent of the time, making interpreting data tricky and limiting the kinds of experiments that can be reliably done.

Inaugural Symposium Encourages Up and Coming Researchers

Inaugural Symposium Encourages Up and Coming Researchers

The College of Natural Sciences will be hosting the inaugural Symposium for Undergraduate Research Exploration (SURE in CNS) this fall to bring bright upper-division undergraduate students from underrepresented backgrounds to The University of Texas at Austin to share their research and explore options to pursue advanced degrees in the sciences.

Mutation in Gene Leads to Variety of Poorly Understood Birth Defects

Mutation in Gene Leads to Variety of Poorly Understood Birth Defects

Scientists have identified genetic mutations that appear to be a key culprit behind a suite of birth defects called ciliopathies, which affect an estimated 1 in 1,000 births. In a paper published online this week in Nature Genetics, a team of researchers led by The University of Texas at Austin's John Wallingford reveals that these mutations prevent certain proteins from working together to smooth the way for cells to communicate with one another.

The Case of the Missing Folate (Audio)

The Case of the Missing Folate (Audio)

When Richard Finnell first met her, Rachel was a nine-year-old girl with severe developmental delays. Her condition seemed to be caused by a deficiency in a critical B vitamin called folate. Yet she had plenty of folate circulating in her blood. Somehow it was vanishing before it got to her brain and spine. Eventually Finnell made a surprising discovery. He's now using new genetic tools like CRISPR to better understand her condition and test possible therapies.

Researchers Discover Why It's So Hard to Grow an Extra Finger

Researchers Discover Why It's So Hard to Grow an Extra Finger

The fact that most humans have five digits on each hand and foot is due in part to a complex developmental pathway called Hedgehog. If something goes wrong in this process during development, say a mutation in a critical gene that affects its expression, a person might be born with extra fingers or toes, a condition known as polydactyly. New research shows that for at least one part of the pathway, there is a sort of failsafe mechanism that seems to make it harder for mistakes to happen.

How Electric Fish Evolved Their Shocking Skills Independently at Six Different Times

How Electric Fish Evolved Their Shocking Skills Independently at Six Different Times

New research demonstrates that the six electric fish lineages, all of which evolved independently, used essentially the same genes and developmental and cellular pathways to make an electricity-generating organ for defense, predation, navigation and communication.

Four Faculty Members Named Fellows of American Association for the Advancement of Science

Faculty chosen for their distinguished efforts to advance science and its applications.

UT Hosts Conference on Neural Tube Defects

This week Austin hosts the 7th International Conference on Neural Tube Defects.

Scientists Find New Genes for Cancer, Other Diseases in Plants, Yeast and Worms

Scientists Find New Genes for Cancer, Other Diseases in Plants, Yeast and Worms

From deep within the genomes of organisms as diverse as plants, worms and yeast, scientists have uncovered new genes responsible for causing human diseases such as cancer and deafness.