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​Some of the same researchers at The University of Texas at Austin who created a key to all coronavirus vaccines used in the U.S. have made a similar advance against the human metapneumovirus (hMPV), one of a handful of remaining respiratory viruses for which there is currently no vaccine.

A new Graduate Portfolio in Computational Medicine combines novel and existing courses from across the University of Texas at Austin to create a unique program in a rapidly expanding medical field.

One of the grand challenges with using CRISPR-based gene editing on humans is that the molecular machinery sometimes makes changes to the wrong section of a host's genome, creating the possibility that an attempt to repair a genetic mutation in one spot in the genome could accidentally create a dangerous new mutation in another.

Scientists think they may have uncovered a whole new approach to fighting antibiotic-resistant bacteria, which, if successful, would help address a health crisis responsible for more deaths every year than either AIDS or malaria.

​Rapid weight gain in the first and final months of a pregnancy may play a key role in the development of excess fat tissue in children and adolescents – at least if those children are girls, according to a new study from researchers at The University of Texas at Austin.

Using cellphone mobility data and COVID-19 hospital admissions data, researchers at The University of Texas at Austin have reliably forecast regional hospital demands for almost two years, according to a new study published in the Proceedings of the National Academy of Sciences. The forecasting system, which municipal authorities credit with helping Austin maintain the lowest COVID-19 death rate among all large Texas cities, has been built out for use by 22 municipal areas in Texas and can be used by any city to guide COVID-19 responses as the virus continues to spread.

Expanding rapid testing stands out as an affordable way to help mitigate risks associated with COVID-19 and emerging variants. Infectious disease researchers at The University of Texas at Austin have developed a new model that tailors testing recommendations to new variants and likely immunity levels in a community, offering a new strategy as public health leaders seek a way out of a pandemic that has so far thwarted the best efforts to end its spread. It is the first study to identify optimal levels of testing in a partially immunized population.

Editor's note: Each December, the journal Science identifies one scientific discovery as its "Breakthrough of the Year." For 2021, this recognition went to AlphaFold and RoseTTA-fold—artificial intelligence software that accurately predicts the 3D structure of proteins. Guest writer and microbiology graduate student Colleen Mulvihill reports on one example of how UT Austin scientists are using the new technology to solve longstanding questions in human health.

Few developments have rocked the biotechnology world or generated as much buzz as the discovery of CRISPR-Cas systems, a breakthrough in gene editing recognized in 2020 with a Nobel Prize. But these systems that naturally occur in bacteria are limited because they can make only small tweaks to genes. In recent years, scientists discovered a different system in bacteria that might lead to even more powerful methods for gene editing, given its unique ability to insert genes or whole sections of DNA in a genome.

Early last year, Jimmy Gollihar was deep into building a unique facility on the Forty Acres, what he calls "the biological foundry" – a turbo-charged, biotech playground with a focus on rapid scientific discovery. The foundry was to be a key element of a partnership in synthetic biology research between The University of Texas at Austin and the U.S. military. Then, as fate would have it, COVID-19 would change everything.