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Sabrina Slater
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Dr Slater holds a Bachelors degree in Biochemistry, and Masters degrees in Molecular Cell Biology and Structural Biology from Imperial College London. After a short stint as a Guest Scientist at the CeMM (Vienna, Austria), she was awarded a BBSRC DTP studentship in 2015, supervised by Prof Gad Frankel at the Centre for Molecular Bacteriology and Infection (CMBI) at Imperial College London.
Her PhD research explored the subversion of mammalian cell processes by type III secretion system (T3SS) effector proteins, secreted from EPEC, EHEC, C. rodentium, V. parahaemolyicus and Shigella spp.. This work was supported in part by an Instruct-ERIC proposal to structurally characterise select effector proteins in collaboration with the Diamond Light Source (Oxford, UK). Dr Slater undertook a sabbatical in 2018 to join Novobind Livestock Therapeutics Inc. (Vancouver, Canada) as an Assay Development Scientist, before returning to complete her PhD. In 2020, Dr Slater relocated from the CMBI to UT Austin with Assistant Professor Despoina Mavridou, in order to persue her postdoctoral research on the bacterial cell envelope. Currently, her interests span oxidative protein folding and colicin biology.
Sabrina is a lifelong learner, and continues to build on her Associate Fellowship from the Higher Education Academy (awarded in 2020) through her commitment to teaching and supervision. She is also an active member of the CNS Staff Diversity and Inclusion Committee, and the Co-founder and Co-Chair of the MBS Postdoctoral Association.
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Slater, S.L., and Mavridou, D.A.I. (2021). Harnessing the potential of bacterial oxidative folding to aid protein production. Mol. Microbiol. 116, 16–28.
Ruano-Gallego, D., Sanchez-Garrido, J., Kozik, Z., Núñez-Berrueco, E., Cepeda-Molero, M., Mullineaux-Sanders, C., Naemi-Baghshomali Clark, J., Slater, S.L., Wagner, N., Glegola-Madejska, I., et al. (2021). Type III secretion system effectors form robust and flexible intracellular virulence networks. Science 371.
Slater, S.L., and Frankel, G. (2020). Advances and Challenges in Studying Type III Secretion Effectors of Attaching and Effacing Pathogens. Front. Cell. Infect. Microbiol. 10.
Sanchez-Garrido, J., Slater, S.L., Clements, A., Shenoy, A.R., and Frankel, G. (2020). Vying for the control of inflammasomes: The cytosolic frontier of enteric bacterial pathogen-host interactions. Cell. Microbiol. 22, e13184.
Goddard, P.J., Sanchez-Garrido, J., Slater, S.L., Kalyan, M., Ruano-Gallego, D., Marchès, O., Fernández, L.Á., Frankel, G., and Shenoy, A.R. (2019). Enteropathogenic Escherichia coli Stimulates Effector-Driven Rapid Caspase-4 Activation in Human Macrophages. Cell Rep. 27, 1008-1017.e6.
Slater, S.L., Sågfors, A.M., Pollard, D.J., Ruano-Gallego, D., and Frankel, G. (2018). The Type III Secretion System of Pathogenic Escherichia coli. Curr. Top. Microbiol. Immunol. 416, 51–72.
Connolly, J.P.R., Slater, S.L., O’Boyle, N., Goldstone, R.J., Crepin, V.F., Ruano-Gallego, D., Herzyk, P., Smith, D.G.E., Douce, G.R., Frankel, G., et al. (2018). Host-associated niche metabolism controls enteric infection through fine-tuning the regulation of type 3 secretion. Nat. Commun. 9, 4187.
Furniss, R.C.D., Slater, S., Frankel, G., and Clements, A. (2016). Enterohaemorrhagic E. coli modulates an ARF6:Rab35 signaling axis to prevent recycling endosome maturation during infection. J. Mol. Biol. 428, 12–19.
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