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Laura L Colgin
Professor, Director, Center for Learning and Memory
Department of Neuroscience, Center for Learning and MemoryInvestigate how brain rhythms affect memory operations, using multisite tetrode recordings from behaving animals.colgin@mail.clm.utexas.edu
Phone: 512-232-6361
Office Location
NHB 2.146
Postal Address
100 E 24TH ST
AUSTIN, TX 78712-
Research Summary:
Brain rhythms reflect synchronized activity across many neurons and thus provide a means for studying how groups of neurons coordinate their activity during complex cognitive functions such as learning. My work uses multisite tetrode recordings from behaving animals to investigate how brain rhythms affect memory operations, particularly in the hippocampus and entorhinal cortex. The main goals of my work are to understand the functional significance of the different types of rhythms within the entorhinal-hippocampal network and to uncover their underlying mechanisms. Understanding the relationship between brain rhythms and behavior, and determining which circuits are involved, is expected to provide novel insights into diseases associated with aberrant rhythmic activity, such as schizophrenia, autism, and Alzheimer's disease.
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2015 Zheng C, Bieri KW, Trettel SG, Colgin LL. The relationship between gamma frequency and running speed differs for slow and fast gamma rhythms in freely behaving rats, Hippocampus, 25(8): 924-938.
2015 Colgin LL. Do slow and fast gamma rhythms correspond to distinct functional states in the hippocampal network?, Brain Research, in press.
2015 Zheng C, Colgin LL. Beta and gamma rhythms go with the flow, Neuron, 85(2): 236-237.
2014 Colgin LL. Theta-gamma coupling in the entorhinal-hippocampal system, Curr Opin Neurobiol, 31C: 45-50.
2014 Bieri KW, Bobbitt KN, Colgin LL. Slow and fast gamma rhythms coordinate different spatial coding modes in hippocampal place cells, Neuron, 82(3): 670-681.
2014 Igarashi KM, Lu L, Colgin LL, Moser MB, Moser EI. Coordination of entorhinal-hippocampal ensemble activity during associative learning. Nature, 510(7503): 143-147.
2013 Colgin LL. Mechanisms and functions of theta rhythms. Annual Review of Neuroscience, 36: 295-312.
2012 Colgin LL. Slow gamma takes the reins in replay. Neuron, 75:549-550.
2012 Colgin LL. Neuroscience: Recalling Space and Time. Science, 336(6082):671.
2011 Colgin LL. Neuroscience: Periodicity without rhythmicity. Nature, 479(7371):46-47.
2011 Colgin LL. Oscillations and hippocampal-prefrontal synchrony. Curr Opin Neurobiol, 21(3): 467-474.
2010 Ellender TJ, Nissen W, Colgin LL, Mann EO, Paulsen O, Priming of hippocampal population bursts by individual perisomatic-targeting interneurons, The Journal of Neuroscience 30(17): 5979-5991
2010 Colgin LL, Moser EI, Gamma oscillations in the hippocampus, Physiology 25(5): 319-329
2010 Henriksen EJ, Colgin LL, Barnes CA, Witter MP, Moser MB, Moser EI, Spatial representation along the proximodistal axis of CA1, Neuron 68(1): 127-137
2010 Colgin LL, Leutgeb S, Jezek K, Leutgeb JK, Moser EI, McNaughton BL, Moser MB, Attractor-map versus autoassociation based attractor dynamics in the hippocampal network, Journal of Neurophysiology 104(1): 35-50
2009 Colgin LL, Denninger T, Fyhn M, Hafting T, Bonnevie T, Jensen O, Moser MB, Moser EI, Frequency of gamma oscillations routes flow of information in the hippocampus, Nature 462(7271) : 353-357 view
2005 Colgin LL, Jia Y, Sabatier JM, Lynch G, Blockade of NMDA receptors enhances spontaneous sharp waves in rat hippocampal slices, Neuroscience Letters 385(1): 46-51
2005 Brunson KL, Kramar E, Lin B, Chen Y, Colgin LL, Yanagihara TK, Lynch G, Baram TZ, Mechanisms of late-onset cognitive decline after early-life stress, The Journal of Neuroscience 25(41): 9328-9338
2004 Colgin LL, Kubota D, Jia Y, Rex CS, Lynch G, Long-term potentiation is impaired in rat hippocampal slices that produce spontaneous sharp waves, Journal of Physiology (London) 558(3): 953-961
2004 Colgin LL, Kubota D, Brucher FA, Jia Y, Branyan E, Gall CM, Lynch G, Spontaneous waves in the dentate gyrus of slices from the ventral hippocampus, Journal of Neurophysiology 92: 3385-3398
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National Science Foundation CAREER Award, 2015
University of Texas at Austin College of Natural Sciences Teaching Excellence Award, 2014
Office of Naval Research Young Investigator Award, 2014
Alfred P. Sloan Research Fellow, 2012
Klingenstein Fellowship Award in the Neurosciences, 2011
Peter and Patricia Gruber International Research Award in Neuroscience, 2010
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