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Haley Tucker
Professor Emerita
Molecular BiosciencesOur group works on transcriptional regulation of stem cells develpment and hematopoiesis-
Research Summary:
We study trancriptional control of fate and differention of stem cells, including those that make blood and those that make placentas. Our interests also include reprogramming somatic cells to stem cells and developing new methodology for producing vaccines. We employ a number of genomic, biochemical and genetic approaches. By understanding normal development we hope to learn what goes wrong to promote hematopoietic malignancy and birth defects.
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Publications:
Wang H, Geng J, Wen X, Bi E, Kossenkov AV, Wolf AI, Tas J, Choi YS, Takata H, Day TJ, Chang LY, Sprout SL, Becker EK, Willen J, Tian L, Wang X, Xiao C, Jiang P, Crotty S, Victora GD, Showe LC, Erikson J, Tucker HO, Hu H. (2014). The transcription factor Foxp1 is a critical negative regulator of the differentiation of follicular helper T cells. Nat Immunol. 2014 May 25. doi: 10.1038/ni.2890. [Epub ahead of print] PMID: 24859450.Popowski M, Lee BK, Templeton T, Liu H, Miner C, Rhee C, Kim J, Iyer VR, Orlanki S, Bergman Y, Webb CF and Tucker H. (2014). The Bright/Arid3a transcription factor provides a singular barrier to somatic cell reprogramming though direct repression of Oct4, Sox2 and Nanog. Cell Stem Cell Reports. 2(1):26-35.Ippolito GC; Dekker JD; Wang Y-S; Shaffer AL; Lin J; Wall JK; Lee B-S; Staudt LM; Liu P; Liu Y-J; Tucker H. (2014). Dendritic cell fate is determined by the BCL11A transcription factor. Proc.Natl. Acad. Sci. ;111(11):998-1006.Leishman E, Howard JM, Garcia CE, Miao Q, Ku A, Dekker JD, Tucker H. (2013). Foxp1 maintains hair follicle stem cell quiescence through regulation of Fgf18. Development: 140(18):3809-18.
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